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pentobarbital will lessen the level or effect of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Solid or average CYP3A4 inducers might improve rate of diazepam elimination; therefore, efficacy of diazepam could be reduced.Following stopping a CYP3A4 inducer, given that the effects from the induc